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Copyright ©The Author(s) 2018.
World J Gastroenterol. Sep 28, 2018; 24(36): 4152-4163
Published online Sep 28, 2018. doi: 10.3748/wjg.v24.i36.4152
Table 2 Predictive and/or prognostic value of biological markers in hepatocellular carcinoma patients
Biological markersPredictive valuePrognostic valueRef.
Serum and plasma proteins
VEGF-ANoUncertain[4,57]
Ang-2NoYes[4]
IGF-1NoNo[55]
Single nucleotide polymorphisms
VEGF-A rs2010963NoYes[65]
VEGF-C rs4604006NoYes[65]
eNOS (eNOS-786/eNOS VNTR)NoYes[66]
Ang-2 rs55633437NoYes[67]
HIF-1 alpha rs12434438NoYes[68]
Amplifications
VEGFNoUncertain[70]
FGF3/FGF4NoUncertain[71]
miRNAs
miR-425-3pNoYes[74]
miR-224NoYes[75]
miR-181a-5pNoYes[77]
miR-339-5pNoYes[77]
miR-423-5pNoYes[78]
miR-10b-3pNoYes[79]
miR-221NoUncertain[76]
Tissue biomarker expression
Phospho-ERKUncertainUncertain[81,82]
PDGFR-bNoYes[84]
c-MetNoNo[84]
VEGFRNoNo[84]
p-c-JunNoYes[85]