Role of microRNAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease

Table 1 MicroRNA targets involved in alcoholic liver disease pathogenesis

miRNA	Source of sample	miRNA target
let-7[27]	Animal models	Lin28, HMGA2
	Human HSCs
miR-19b[28]	Animal models	TGFβRII, Col1α2, MeCP2
	Human HSCs
miR-21[36,37]	Animal models	FASLG, DR5, Crebl2
miR-26a[35]	Animal models	DUSP4, DUSP5
miR-27a[44,52]	Animal models	Sprouty2, CD206
	HMC
	Humans (plasma)
miR-34a[29,43]	Animal models	SIRT1, CASP2
	Human HSCs
	NHH
	HiBECs
	Humans (liver biopsy)
miR-103 and miR-107[53]	Humans (liver biopsy)	Caveolin-1
miR-122[32,124,125]	Animal models	P4HA1, HO-1, Cyclin G1, Bcl-w, HIF-1α
miR-155[38,39,97,126,127]	Animal models	TNFα, SHIP1, SOCS1, IRAKM, C/EBPβ
miR-181b-3p[40]	Animal models	Importin α1
miR-182[30]	Animal models	SLC1A1, Cofilin 1, CCL20, CXCL1, IL-8, Cyclin D1, IL-6
	Humans (serum samples and liver biopsy)
miR-199[128]	Animal models	ET-1, ET-BR
miR-200a[31]	Animal models	ZEB-2
miR-212[46]	Caco-2 cells	ZO-1
	Humans (colon biopsy)
miR-214[24,34]	Animal models	POR, GSR, CYP2E1
	HHCs
miR-217[41]	Animal models	SIRT-1
miR-223[45]	Animal models	p47phox, IL-6
	Humans (serum)
miR-291b[42]	Animal models	Tollip
	HPBMs
miR-378[59]	Animal models	Gli-3
miR-497[25]	Animal models	Btg2, Yy1

HSCs: Hepatic stellate cells; HMGA2: High mobility group AT-hook 2; TGFβRII: Transforming growth factor β receptor II; Col1α2: Collagen type I α 2 chain; MeCP2: Methyl-CpG binding protein 2; FASLG: Fas ligand; DR5: Death receptor 5; Crebl2: cAMP responsive element binding protein like 2; DUSP: Dual specificity phosphatase; HMC: Human Monocyte Cells; NHH: Normal Human Hepatocytes; HiBECs: Human intrahepatic Biliary Epithelial Cells; SIRT1: sirtuin 1; CASP2: caspase 2; P4HA1: prolyl 4-hydroxylase subunit α 1; HO-1: heme oxygenase-1; BCL-W: Bcl-2-like protein 2; HIF-1α: Hypoxia inducible factor 1 α; TNFα: Tumor necrosis factor α; SHIP1: Src homology 2 domain-containing inositol phosphatase 1; SOCS1: Suppressor of cytokine signaling 1; IRAKM: Interleukin 1 receptor associated kinase 3; C/EBPβ: CCAAT/enhancer binding protein β; SLC1A1: Solute carrier family 1 member 1; CCL20: C-C motif chemokine ligand 20; CXCL1: C-X-C motif chemokine ligand 1; IL: Interleukin; ET-1: Endothelin-1; ET-BR: Endothelin-B receptor; ZEB-2: Zinc finger E-box binding homeobox 2; ZO-1: Zonula occludens 1; HHCs: Human Hepatoma Cells; POR: Cytochrome P450 oxidoreductase; GSR: Glutathione reductase; CYP2E1: Cytochrome P450 2E1; p47phox: Neutrophil cytosolic factor 1-like; HPBMs: Human Peripheral Blood Monocytes; Tollip: Toll interacting protein; Gli3: GLI Family Zinc Finger 3; Btg2: B-cell translocation gene 2; YY1: Yin yang 1; miRNA: MicroRNA.