Changing role of histopathology in the diagnosis and management of hepatocellular carcinoma

Figure 4 Dysplastic lesions and early hepatocellular carcinoma. Gross morphology of small distinctly nodular HCC (A); small vaguely nodular HCC (B, C); HCC with nodule in nodule appearance (D). Microphotographs of large cell change (E) and small cell change (F) in dysplastic nodules. Nodule in nodule with low grade dysplasia surrounding central high grade dysplastic nodule (G) on HE stain and focal CD34 positive (H) on immunohistochemistry. Glypican-3 (I), glutamine synthetase (J), HSP-70 (K) and diffuse CD34 (L) immunostaining in well-differentiated HCC. HCC: Hepatocellular carcinoma.