Drug resistance and new therapies in colorectal cancer

Figure 3 Combination therapies for the development of durable colorectal cancer responses. Durable cancer responses are impeded by a dysfunctional immunological control. Strategies aiming to boost T cell-mediated immune responses will most likely need the combination of therapies that counter the tumor and their environment-mediated escape mechanisms avoiding T-cell recognition as well as down-regulation of T-cell mediated functions. In this figure, we list potential interesting combinations leading to durable T-cell mediated killing for CRC. CRC: Colorectal cancer; VEGF: Vascular endothelial growth factor.