Gastroduodenal ulcer bleeding in elderly patients on low dose aspirin therapy

Table 4 Comparison between the severe and non-severe groups in the elderly group

	Elderly group (n = 436)		Univariate analysis	Multivariate analysis
	Severe cases (n = 51)	Non-severe cases (n = 385)	P value	OR (95%CI)	P value
Mean age (yr)	79.0	78.8	0.846
Sex (male:female)	64.7% (33:18)	61.8% (238:147)	0.689
Mean length of hospital stay (d)
After endoscopic treatment	21.9	23.5	0.699
Overall	25.9	27.0	0.823
Hb (mg/L)	76.3	81.4	0.113
Hb decrease (present:absent)	70.0% (35:15)	52.1% (198:182)	0.017	1.378 (0.693-2.74)	0.361
Blood transfusion (present:absent)	88.0% (44:6)	62.4% (237:143)	< 0.001	3.592 (1.423-9.064)	0.007
H. pylori infection (positive:negative)	69.8% (30:13)	78.9% (281:75)	0.171
Forrest (I:II, III)	45.1% (23:28)	22.9% (88:297)	0.001	2.395 (1.065-4.537)	0.007
Ulcer (multiple:single)	31.4% (16:35)	41.3% (159:226)	0.174
HSE use	21.6% (11:40)	9.6% (37:348)	0.010	2.178 (0.975-4.862)	0.058
DM	29.4% (15:36)	16.9% (65:320)	0.030	2.018 (1.002-4.063)	0.049
Cardiac disease	29.4% (15:36)	34.5% (133:252)	0.467
Cerebrovascular disorder	27.5% (14:37)	21.6% (83:302)	0.342
Orthopedic disorder	23.5% (12:39)	21.3% (82:303)	0.716
Respiratory disease	21.6% (11:40)	14.0% (54:331)	0.155
Renal disease	5.9% (3:48)	14.0% (54:331)	0.105
History of peptic ulcer	23.5% (12:39)	17.7% (68:317)	0.309
Hypertension	41.2% (21:30)	45.7% (176:209)	0.541
Preceding anti-ulcer medication	52.9% (27:24)	39.7% (153:232)	0.072
Preceding PPI medication	11.8% (6:45)	11.7% (45:340)	0.987

Hb: Hemoglobin; H. pylori: Helicobacter pylori; IVR: Interventional radiology; HSE: Hypertonic saline epinephrine; DM: Diabetes mellitus; PPI: Proton pump inhibitor.