Gastroduodenal ulcer bleeding in elderly patients on low dose aspirin therapy

Table 3 Characteristics of low dose aspirin therapy

	Elderly patients (n = 111)		Non-elderly patients (n = 99)		P (A vs B)	P (A vs C)
	Group A: LDA monotherapy (n = 63)	Group B: LDA combination therapy (n = 48)	Group C: LDA monotherapy (n = 49)	Group D: LDA combination therapy (n = 50)
Mean age (yr)	80.0	80.0	58.3	60.7	0.989	< 0.001
Sex (male:female)	43:20:00	34:14:00	45:04:00	44:06:00	0.770	0.003
Mean length of hospital stay (d)
After endoscopic treatment	20.0	25.5	20.9	21.9	0.194	0.323
Overall	20.1	28.4	23.0	27.3	0.120	0.685
Hb (mg/L)	84.0	84.0	89.0	86.0	0.948	0.307
Hb decrease (present:absent)	43.5% (27:35)	53.2% (25:22)	49.0% (24:25)	67.4% (31:15)	0.702	0.569
Blood transfusion (present:absent)	61.3% (38:24)	66.0% (31:16)	38.8% (19:30)	58.7% (27:19)	0.690	0.018
H. pylori infection (positive:negative)	77.4% (48:14)	68.3% (28:13)	80.9% (38:9)	68.8% (33:15)	0.303	0.664
Forrest (I:II, III)	23.8% (15:48)	27.1% (13:35)	16.3% (8:41)	20.0% (10:40)	0.694	0.331
Ulcer (multiple:single)	42.9% (27:36)	39.6% (19:29)	22.4% (11:38)	46.0% (23:27)	0.846	0.024
Rebleeding (present:absent)	3.2% (2:61)	12.5% (6:42)	2.0% (1:48)	8.0% (4:46)	0.060	1.000
Rebleeding/surgery/IVR/death (present:absent)	3.2% (2:61)	14.6% (7:41)	4.1% (2:47)	8.0% (4:46)	0.038	1.000
Recurrence (present:absent)	0% (0:63)	4.2% (2:46)	8.2% (4:45)	4.0% (2:48)	0.185	0.034
DM	17.5% (11:51)	25.0% (12:36)	36.7% (18:31)	36.0% (18:32)	0.332	0.021
Cardiac disease	52.4% (33:30)	66.7% (32:16)	46.9% (23:26)	78.0% (39:11)	0.130	0.568
Cerebrovascular disorder	38.1% (24:39)	39.6% (19:29)	22.4% (11:38)	34.0% (17:33)	0.873	0.076
Orthopedic disorder	12.7% (8:55)	25.0% (12:36)	6.1% (3:46)	20.0% (10:40)	0.095	0.342
Respiratory disease	17.5% (11:52)	14.6% (7:41)	4.1% (2:47)	4.0% (2:48)	0.684	0.028
Renal disease	12.7% (8:55)	22.9% (11:37)	18.4% (9:40)	24.0% (12:38)	0.157	0.407
History of peptic ulcer	19.0% (12:51)	12.5% (6:42)	28.6% (14:35)	20.0% (10:40)	0.354	0.236
Hypertension	49.2% (31:32)	52.1% (25:23)	36.7% (18:31)	42.0% (21:29)	0.764	0.187
Preceding anti-ulcer medication (present:absent)	38.1% (24:39)	79.2% (38:10)	44.9% (22:27)	58.0% (29:21)	< 0.001	0.468
Preceding PPI medication	11.1% (7:56)	22.9% (11:37)	12.2% (6:43)	16.0% (8:42)	0.095	0.853

Hb: Hemoglobin; LDA: Low dose aspirin; H. pylori: Helicobacter pylori; IVR: Interventional radiology; PPI: Proton pump inhibitor; DM: Diabetes mellitus.