Role of two-dimensional shear wave elastography in chronic liver diseases: A narrative review

Table 4 Diagnostic performance of shear wave elastography for significant fibrosis (F ≥ 2), advanced fibrosis (F ≥ 3) and cirrhosis (F4) in patients with non-viral liver diseases

Ref.	Year	Etiology	Patients (n)	F ≥ 2 (%)	F ≥ 3 (%)	F = 4 (%)	AUROC	Cutoffs (kPa)	Se (%)	Sp (%)	PPV (%)	NPV (%)
Cassinotto et al[20]	2016	NAFLD	291	70.8			0.860	8.90	68.0	94.0
					43.3		0.890	9.30	84.0	83.0
						16.8	0.880	10.00	95.0	69.0
Takeuchi et al[58]	2018	NAFLD	71	64.8			0.750	11.57	52.0	44.0
					45.1		0.820	13.07	63.0	57.0
						7.0	0.900	15.73	100.0	82.0
Herrmann et al[49]	2018	NAFLD	156	58.3			0.855	7.10	93.8	52.0
					32.1		0.928	9.20	93.1	80.9
						12.2	0.917	13.00	75.3	87.8
Thiele et al[19]	2016	Alcohol	199	42.0			0.940	10.20	82.0	93.0	90.0	88.0
						18.0	0.950	16.40	94.0	91.0	71.0	99.0
Zeng et al[59]	2017	Autoimmune	114	71.9			0.850	9.70	81.7	81.3	91.8	63.4
					41.3		0.850	13.20	83.0	74.6	69.6	86.2
						20.2	0.860	16.30	87.0	80.2	52.6	96.1
Li et al[60]	2018	Autoimmune	51	35.2			0.781	9.15	83.3	72.7

AUROC: Area under ROC curve; Se: Sensitivity; Sp: Specificity; PPV: Positive predictive value; NPV: Negative predictive value; NAFLD: Non-alcoholic fatty liver disease