Role of two-dimensional shear wave elastography in chronic liver diseases: A narrative review

Table 2 Diagnostic performance of shear wave elastography for significant fibrosis (F ≥ 2), advanced fibrosis (F ≥ 3) and cirrhosis (F4) in patients with chronic hepatitis C

Ref.	Year	Patients (n)	F ≥ 2 (%)	F ≥ 3 (%)	F = 4 (%)	AUROC	Cutoffs (kPa)	Se (%)	Sp (%)	PPV (%)	NPV (%)
Bavu et al[46]1	2011	113	55.8			0.950	9.12	81.0	72.0
				34.5		0.960	10.08	75.0	78.0
					13.3	0.970	13.30	80.0	87.0
Ferraioli et al[47]	2012	121	58.7			0.920	7.10	90.0	87.5	91.3	85.7
				31.4		0.980	8.70	97.3	95.1	90.0	98.7
					19.8	0.980	10.40	87.5	96.8	87.5	96.8
Tada et al[48]	2013	55	32.7			0.940	8.80	88.9	91.9	84.2	94.4
Herrmann et al[49]	2018	379	58.3			0.863	7.10	94.7	52.0
				33.5		0.915	9.20	90.3	76.8
					18.2	0.929	13.00	85.8	87.8

¹The reference fibrosis level is derived from the algorithm proposed by Sebastiani et al[79]. AUROC: Area under ROC curve; Se: Sensitivity; Sp: Specificity; PPV: Positive predictive value; NPV: Negative predictive value.