Differentiation of intrahepatic cholangiocarcinoma from hepatocellular carcinoma in high-risk patients: A predictive model using contrast-enhanced ultrasound

Table 5 Comparison of the AUC, NRI and IDI of the contrast-enhanced ultrasound score nomogram vs contrast-enhanced ultrasound liver imaging reporting and data system nomogram in distinguishing intrahepatic cholangiocarcinoma from hepatocellular carcinoma

	AUC	(95%CI)	P value	NRI	(95%CI)	P value	IDI	(95%CI)	P value
Training set (n = 117)
CEUS LI-RADS nomogram	0.891	(0.834, 0.948)	< 0.001	0.446	(0.263, 0.629)	< 0.001	0.210	(0.140, 0.280)	< 0.001
CEUS score nomogram	0.971	(0.948, 0.995)
Validation set (n = 59)
CEUS LI-RADS nomogram	0.916	(0.854, 0.978)	0.036	0.077	(-0.141, 0.295)	0.488	0.152	(0.044, 0.260)	0.006
CEUS score nomogram	0.973	(0.941, 1.000)
≤ 5.0 cm subgroup (n = 59)
CEUS LI-RADS nomogram	0.835	(0.744, 0.926)	0.008	0.382	(0.069, 0.695)	0.017	0.177	(0.065, 0.289)	0.002
CEUS score nomogram	0.929	(0.870, 0.988)
≤ 3.0 cm subgroup (n = 19)
CEUS LI-RADS nomogram	0.881	(0.732, 1.000)	0.601	-0.202	(-0.572, 0.167)	0.283	-0.117	(-0.284, 0.050)	0.171
CEUS score nomogram	0.905	(0.772, 1.000)

Numbers are raw data. P values were CEUS Score nomogram vs CEUS LI-RADS nomogram. AUC: Area under the ROC curve; NRI: Net reclassification improvement; IDI: Integrated discriminatory improvement; CEUS: Contrast-enhanced ultrasound; LI-RADS: Liver imaging reporting and data system; ICC: Intrahepatic cholangiocarcinoma; HCC: Hepatocellular carcinoma.