Differentiation of intrahepatic cholangiocarcinoma from hepatocellular carcinoma in high-risk patients: A predictive model using contrast-enhanced ultrasound

Table 3 Comparison of the diagnostic performance of the contrast-enhanced ultrasound score vs contrast-enhanced ultrasound liver imaging reporting and data system in distinguishing intrahepatic cholangiocarcinoma from hepatocellular carcinoma

	Sensitivity	Specificity	PPV	NPV	Accuracy	AUC	(95%CI)	P value
Training set (n = 117)
CEUS LI-RADS	0.936	0.691	0.773	0.905	0.821	0.813	(0.744, 0.882)	0.000
CEUS score	0.871	0.946	0.947	0.867	0.906	0.958	(0.924, 0.993)
Validation set (n = 59)
CEUS LI-RADS	1.000	0.485	0.605	1.000	0.712	0.742	(0.656, 0.829)	0.000
CEUS score	0.885	0.909	0.885	0.909	0.898	0.953	(0.907, 0.999)
≤ 5.0 cm subgroup (n = 59)
CEUS LI-RADS	0.917	0.600	0.611	0.913	0.729	0.758	(0.658, 0.858)	0.000
CEUS score	0.750	0.886	0.818	0.838	0.831	0.902	(0.824, 0.980)
≤ 3.0 cm subgroup (n = 19)
CEUS LI-RADS	0.857	0.750	0.667	0.900	0.790	0.804	(0.614, 0.993)	0.512
CEUS score	0.571	0.917	0.800	0.786	0.790	0.833	(0.636, 1.000)

Numbers are raw data. P values were CEUS Score vs CEUS LI-RADS. CEUS: Contrast-enhanced ultrasound; LI-RADS: Liver imaging reporting and data system; ICC: Intrahepatic cholangiocarcinoma; HCC: Hepatocellular carcinoma; PPV: Positive predictive value; NPV: Negative predictive value; AUC: Area under the ROC curve.