Differentiation of intrahepatic cholangiocarcinoma from hepatocellular carcinoma in high-risk patients: A predictive model using contrast-enhanced ultrasound

Table 1 Demography of patients with intrahepatic cholangiocarcinoma or hepatocellular carcinoma n (%)

Characteristic	Training set (n = 117)		Validation set (n = 59)		P value
	ICC	HCC	ICC	HCC
Number of patients	56 (47.9)	61 (52.1)	32 (27.4)	27 (23.1)	0.425
Gender					0.148
Male	35 (29.9)	56 (47.9)	24 (20.5)	21 (17.9)
Female	21 (17.9)	5 (4.3)	8 (6.8)	6 (5.1)
Age (yr)1	55 ± 11 (32-84)	55 ± 11 (32-84)	53 ± 10 (18-76)	57 ± 11 (33-82)	0.646
Hepatitis status					0.627
Hepatitis B	53 (45.3)	59 (50.4)	31 (26.5)	27 (23.1)
Hepatitis B + C	3 (2.6)	2 (1.7)	1 (0.9)	0 (0)
AFP > 20 (μg/L)	11 (9.4)	29 (24.8)	3 (2.6)	11 (9.4)	0.655
CA 19-9 > 35 (U/mL)	22 (18.8)	6 (5.1)	15 (12.8)	3 (2.6)	0.691
Nodule size					0.782
≤ 3.0 cm	5 (4.3)	9 (7.7)	2 (1.7)	3 (2.6)
3.1-5.0 cm	9 (7.7)	17 (14.5)	8 (6.8)	6 (5.1)
> 5.0 cm	42 (35.9)	35 (29.9)	22 (18.8)	18 (15.4)
Number of nodules					0.156
One	39 (33.3)	42 (35.9)	25 (21.4)	24 (20.5)
Multiple	17 (14.5)	19 (16.2)	7 (6.0)	3 (2.6)

¹Data are means ± SD, with ranges in parentheses. Unless otherwise indicated, data are number of nodules, with percentages in parentheses. ICC: Intrahepatic cholangiocarcinoma; HCC: Hepatocellular carcinoma.