Metabolomic alterations and chromosomal instability status in gastric cancer

doi:10.3748/wjg.v24.i33.3760

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 7, 2018; 24(33): 3760-3769
Published online Sep 7, 2018. doi: 10.3748/wjg.v24.i33.3760

Table 5 Altered metabolites with statistical significance between chromosomal instability and non-chromosomal instability types

	Metabolites		VIP score (VIP > 1.2)	Fold change (tumor/healthy > 1.2 or < 0.8)	P value (P < 0.05)
CIN tumor	Increased	Aspartic acid	1.309	2.029	0.043
		Citicoline	1.751	2.886	0.033
		Glutamic acid	1.219	2.101	0.011
		Oxidized glutathione	1.642	2.249	0.018
		Succinyladenosine	1.671	3.434	0.011
		Uridine diphosphate-N-acetylglucosamine	1.264	2.006	0.036
	Decreased	Butyrylcarnitine	1.218	0.590	0.014
		Glutathione	1.214	0.582	0.042
		Hydroxyhexanoycarnitine	1.883	0.397	0.013
		Inosinic acid	1.572	0.506	0.008
		Isovalerylcarnitine	1.657	0.346	0.004
		Threonine	1.714	0.394	0.006
non-CIN tumor	Increased	Glutamic acid	1.424	1.688	0.031
		Oxidized glutathione	1.678	1.676	0.019
		Proline	1.542	1.569	0.003
		Succinyladenosine	1.929	3.207	0.031
		Xanthine	2.360	2.085	0.007
	Decreased	NAD	1.584	0.599	0.047

VIP: Variable importance in the projection; CIN: Chromosomal instability; NAD: Nicotinamide adenine dinucleotide.

Citation: Tsai CK, Yeh TS, Wu RC, Lai YC, Chiang MH, Lu KY, Hung CY, Ho HY, Cheng ML, Lin G. Metabolomic alterations and chromosomal instability status in gastric cancer. World J Gastroenterol 2018; 24(33): 3760-3769
URL: https://www.wjgnet.com/1007-9327/full/v24/i33/3760.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i33.3760