Updates on the hepatocyte growth factor/c-Met axis in hepatocellular carcinoma and its therapeutic implications

Table 3 List of compounds analyzed in laboratories that show potential anti-tumor properties against hepatocellular carcinoma

Agent	Target	Activity	Ref.
LZ8	Inhibits the expression of c-Met, ERK, AKT	Induces apoptosis	[112]
	Inhibits the phosphorylation of JNK, AKT, ERK, p-AKT
	Stabilizes p53
Damnacanthal	Inhibits the phosphorylation of c-Met	Inhibits cell proliferation and cell invasion	[113]
	Decreases MMP-2 activity
GEN-203	Inhibits the phosphorylation of c-Met	Blocks cell proliferation	[114]
JNJ38877605	Inhibits phosphorylation of c-Met	Induces apoptosis	[70]
SRI31215	Blocks pro-HGF activation	Inhibits cell proliferation	[70]
Madecassoside	Inhibits the phosphorylation of ERK1/2 and	Blocks cell proliferation	[115]
	PKC
PHA665752	Inhibits phosphorylation of c-Met and FGFR	Blocks cell proliferation	[116]
EPZ011989	Inhibits histone methylation	Blocks cell proliferation	[82]
YC-1	Inhibits the DNA synthesis	Arrests cell cycle and induce apoptosis	[117]