Updates on the hepatocyte growth factor/c-Met axis in hepatocellular carcinoma and its therapeutic implications

Table 1 MicroRNA involved in hepatocellular carcinoma and their function in the hepatocyte growth factor/c-Met axis

miRNA	Functions	Effect of miR in HGF/c-Met axis	Levels in HCC	Ref.
miR-34	Cell invasion, proliferation	Inhibits c-Met	Downregulated	[83]
miR-199	Proliferation, cell motility,	Tumor-suppressor	Downregulated	[84]
	cell invasion
miR-340	Cell invasion, cell migration	Inhibits c-Met	Downregulated	[85]
miR-126	Cell proliferation,	Inhibits c-Met	Downregulated	[86]
	cell invasion, inhibits angiogenesis
miR181-a	Cell motility and invasion	Inhibits c-Met	Upregulated	[87]
let-7 family	Represses cell proliferation, invasion, metastasis and resistance therapy	Inhibits c-Met signaling downstream	Downregulated	[88,89]
miR-148	Promotes apoptosis, suppress cell invasion	Tumor-suppressor	Downregulated	[90]
miR-1	Cell migration, cell proliferation	Tumor-suppressor	Downregulated	[91]
miR-26a	Cell proliferation, invasion, and migration	Inhibits c-Met signaling downstream	Downregulated	[92]
miR-122	Induces apoptosis	Inhibition of c-Met	Downregulated	[93]
miR-145	Cell viability, cell migration	Inhibits c-Met signaling downstream	Downregulated	[94]
miR-449	Promotes apoptosis, reduces proliferation	Decreases c-Met levels	Downregulated	[95]
miR-200	Cell migration and invasion	Decreases HGF-synthesis in fibroblasts	Upregulated	[96]
miR-101	Cell proliferation, migration and invasion	Inhibits c-Met signaling downstream	Downregulated	[97]

HCC: Hepatocellular carcinoma; HGF: Hepatocyte growth factor.