Abnormal expression of HMGB-3 is significantly associated with malignant transformation of hepatocytes

Figure 2 HMGB3 mRNA expression related to hepatocellular carcinoma by bioinformatic databases. Comparative analysis of human normal livers (n = 359) and HCC (n = 765) tissues from bioinformatics databases suggested that the upregulation of hepatic HMGB3 mRNA might be involved in HCC progression. The data of HMGB3 mRNA in HCC or normal liver were extracted from A: GSE-14520, B: GSE-5364, C: GSE-77314, D: the HMGB3 mRNA in TCGA database, E: GSE-50579, and F: the HMGB3 mRNA in Oncomine database. Values were presented as Log2 median centered intensity. ^aP < 0.05; ^bP < 0.01.GSE and GEO Series; TCGA: The Cancer Genome Atlas; HCC: Hepatocellular carcinoma.