Expansion of the hepatocellular carcinoma Milan criteria in liver transplantation: Future directions

Table 4 Impact of genetic and molecular factors in post-liver transplantation outcome

Ref.	Criteria	Survival, time and rate (%)	Recurrence, time and rate (%)
Schwartz et al[68], 2008	FAI < 0.27		5 yr (10)
Dvorchick et al[69], 2008	FAI and macrovascular invasion (Pittsburg criteria)	Stage I (FAI ≤ 20% and no macrovascular invasion) - 5 yr DFS (92.8)
Miltiadous et al[67], 2015	Progenitor cell markers (CK19 or S2 signature)	5 yr (67)	5 yr (19)
Sugimachi et al[70], 2015	miR-718 and his target gene HOXB8	5 yr (≈ 80)
Barry et al[71], 2012	67 miRNA
Liese et al[72], 2016	miR-214, miR-3187 and MC	5 yr DFS (≈ 90)

DFS: Disease-free survival; FAI: Fractional allelic imbalance; MC: Milan criteria; miRNA: MicroRNA.