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©The Author(s) 2018.
World J Gastroenterol. Aug 21, 2018; 24(31): 3513-3520
Published online Aug 21, 2018. doi: 10.3748/wjg.v24.i31.3513
Published online Aug 21, 2018. doi: 10.3748/wjg.v24.i31.3513
Agent | Treatment | No. of patients (n) | BMD changes at 1 yr (%) | BMD changes at 2 yr (%) | Fractures (n) |
Etidronate | 400 mg/d (3 mo cycles) | 6 (etidronate) | +1.0 (L), +0.2 (F) | N/A | 0 |
Wolfhagen et al[43], 1997 | 6 (no treatment)3 | -1.7 (L), +0.4 (F) | 0 | ||
Lindor et al[6], 2000 | 400 mg/d (3 mo cycles) | 29 (etidronate) | +0.7 (L), +1.3 (F) | +1.0 (L), +0.5 (F) | 4 (V) |
31 (placebo) | -0.6 (L), +0.9 (F) | +2.6 (L), +0.8 (F) | 4 (V) | ||
Alendronate | 70 mg/wk | 15 (alendronate) | +10.4 (L)12, +1.4 (F)1 | N/A | 1 (V), 0 (P) |
Zein et al[44], 2005 | 13 (placebo) | -0.1 (L)1, -2.1 (F)1 | 0 (V), 1 (P) | ||
HRT | 50 mcg twice weekly TD estradiol + 2.5 mg/d progestin | 8 (HRT) | +3.1 (L)2, +1.7 (F)12 | N/A | 0 |
Ormarsdottir et al[51], 2004 | 9 (no treatment)3 | +1.0 (L), -0.6 (F)1 | 0 | ||
Boone et al[9], 2006 | 0.05 mg/d TD estradiol + 0.25 mg/d TD progestin | 8 (HRT) | N/A | -0.6 (L), +0.2 (F) | 0 (V) |
14 (placebo) | -0.8 (L), -3.7 (F)2 | 2 (V) | |||
Sodium fluoride | 50 mg/d sodium fluoride | 8 (fluoride) | N/A | +2.9 (L)1 | 0 |
Guañabens et al[7], 1992 | 8 (placebo) | -6.6 (L)12 | 0 | ||
Calcitriol | 0.5 mcg/d BID calcitriol | 17 (calcitriol) | +0.1 (L)1 | N/A | N/A |
Shiomi et al[38], 1999 | 17 (no treatment)3 | -3.1 (L)1 | |||
Vitamin K | 45 mg/d vitamin K2 | 15 (vitamin K) | +0.3 (L)1 | -0.8 (L)1 | N/A |
Nishiguchi et al[57], 2001 | 15 (no treatment)3 | -3.5 (L)1 | -6.9 (L)1 |
- Citation: Danford CJ, Trivedi HD, Papamichael K, Tapper EB, Bonder A. Osteoporosis in primary biliary cholangitis. World J Gastroenterol 2018; 24(31): 3513-3520
- URL: https://www.wjgnet.com/1007-9327/full/v24/i31/3513.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i31.3513