Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studies

Figure 1 Associations within the human leukocyte antigen locus identified by genome-wide association studies for hepatitis B virus-related traits. GWAS hits for HBV-related pathologies are concentrated on the HLA region. Top SNPs in each GWAS are demonstrated in rows in the chronological order of publication; red for HBV persistence, green for Hepatitis B vaccine non-response, and blue for advanced HBV-related liver diseases. The nearest genes for the identified SNPs are colored in red; HLA-A and HLA-B are also marked. GWAS: Genome-wide association studies; HLA: Human leukocyte antigen; HBV: Hepatitis B virus; SNPs: Single nucleotide polymorphisms.