Altered oral microbiota in chronic hepatitis B patients with different tongue coatings

Table 2 Metabolites detected in the tongue coatings

Metabolites	Formula	Rt (min)	Type	KEGG compounds	VIP	P (corr)	CHB VS H		Healthy	CHBWhite tongue coating	CHBYellow tongue coating
							P value	FC
L-Proline	C5H9NO2	83.3392	[M+H]+	C00148	1.04	-0.68	0.134	1.473	1.01 (0.13-12)	3 (0.16-20.14)	3.88 (0.09-15.28)
L-Valine	C5H11NO2	120.7915	[M+H]+	C00183	1.07	-0.76	0.081	1.608	2.92 (0.82-17.97)	3.98 (1.13-38.65)	7.44 (1.08-31.3)
L-Isoleucine	C6H13NO2	194.3545	[M+H]+	C00123	1.15	-0.81	0.069	1.641	5.55 (0.43-30.81)	7.23 (1.23-58.36)	13.28 (0.22-45.18)
L-Leucine	C6H13NO2	212.576	[M+H]+	C00123	1.07	-0.81	0.029	1.715	8.9 (0.02-44.58)	14.65 (2.89-84.8)	21.6 (0.44-61.98)
Hypoxanthine	C5H4N4O	154.305	[M+H]+	C00262	1.07	-0.80	0.039	2.218	0.42 (0.01-6.93)	1.31 (0.05-17.87)	2.46 (0.01-14.33)
Urocanic acid	C6H6N2O2	132.3225	[M+H]+	C00785	1.00	-0.78	0.044	2.587	0.62 (0.07-4.46)	0.93 (0.08-12.84)	1.93 (0.08-13.92)
L-Lysine	C6H14N2O2	64.124	[M+H]+	C00047	1.01	-0.72	0.683	1.510	0.08 (0.05-0.28)	0.08 (0.03-0.81)	0.08 (0.03-0.65)
Glutamate	C5H9NO4	76.6581	[M+H]+	C00025	1.04	-0.75	0.159	1.955	0.14 (0.02-1.17)	0.2 (0-2.99)	0.39 (0-2.52)
Methionine	C5H11NO2S	131.208	[M+H]+	C00073	1.16	-0.80	0.144	1.543	1.08 (0.01-7.21)	1.74 (0.13-10.21)	2.26 (0-9.75)
Xanthine	C5H4N4O2	183.102	[M+H]+	C00385	1.01	-0.73	0.151	2.058	0.09 (0-2.91)	0.24 (0-4.93)	0.47 (0-4.75)
L-Phenylalanine	C9H11NO2	277.369	[M+H]+	C00079	1.17	-0.82	0.069	1.534	6.72 (0.83-24.15)	11.07 (1.84-51.35)	13.1 (0.31-36.18)
Glycyl-Valine	C7H14N2O3	205.364	[M+H]+		1.07	-0.70	0.078	1.548	0.07 (0-1.1)	0.15 (0-0.84)	0.19 (0-1.38)
Citrulline	C6H13N3O3	77.3246	[M+H]+	C00327	1.16	-0.74	0.216	1.486	0.12 (0-1.28)	0.14 (0.01-1.7)	0.3 (0-1.38)
L-Tyrosine	C9H11NO3	204.441	[M+H]+	C00082	1.17	-0.81	0.095	1.512	2.63 (0.33-11.35)	4.36 (0.71-22.15)	5.67 (0.1-16.28)
Benzophenone	C13H10O	882.111	[M+H]+	C06354	1.19	0.81	< 0.001	0.752	0.25 (0.16-0.3)	0.19 (0.1-0.3)	0.18 (0.07-0.25)
L-Tryptophan	C11H12N2O2	338.856	[M+H]+	C00078	1.03	-0.74	0.23	1.940	0.57 (0.09-3.63)	0.74 (0.07-12.67)	1.11 (0.1-9.81)
12-Hydroxylauric acid	C12H24O3	906.316	[M+H]+	C08317	1.12	0.72	< 0.001	0.697	10.81 (8.25-16.18)	7.3 (0.08-12.49)	7.61 (0.08-14.08)
N-Acetyl-D-glucosamine	C8H15NO6	82.3978	[M+H]+	C03878	1.02	-0.39	0.936	0.942	0.04 (0-0.46)	0.07 (0-0.34)	0.07 (0-0.44)
L-cystathionine	C7H14N2O4S	836.2685	[M+H]+	C02291	1.10	0.67	0.24	0.919	0.48 (0.31-0.79)	0.48 (0.2-0.81)	0.43 (0.22-0.66)
S-adenosyl-L-methionine	C15H22N6O5S	66.1963	[M+H]+	C00019	1.02	0.79	0.029	0.888	9.98 (8.09-12.77)	9.2 (4.71-12.09)	8.58 (4.98-14.58)
Guanosine	C10H13N5O5	230.687	[M+H]-	C00387	1.01	0.02	0.824	0.763	3.02 (0.55-14.19)	2.98 (0-10.27)	3.52 (0-10.89)