Identification of a five-long non-coding RNA signature to improve the prognosis prediction for patients with hepatocellular carcinoma

Table 3 Univariate and multivariate Cox regression analysis of overall survival

Variables	Univariate analysis			Multivariate analysis
	HR	95%CI of HR	P value	HR	95%CI of HR	P value
Training set (n = 184)
Risk score	2.718	2.093-3.530	< 0.0001	2.830	2.091-3.831	< 0.0001
Age	1.018	0.998-1.038	0.073
Sex (Male/Female)	1.022	0.619-1.690	0.931
Weight	1.006	0.993-1.108	0.397
Child-Pugh grade	0.845	0.253-2.827	0.195
Fibrosis ishak score	0.685	0.756-1.283	0.910
Vascular invasion (yes/no)	0.834	0.480-1.449	0.519
FAP	0.805	0.932-1.056	0.805
Tumor grade
(G1 + G2/G3 + G4)	1.133	0.680-1.887	0.632
Pathologic stage				1.900	1.098-3.288	0.022
I/II	0.604	0.303-1.203	0.152
I/III + IV	0.298	0.163-0.543	< 0.0001
Test set (n = 186)
Risk score	1.603	1.270-2.024	< 0.0001	1.568	1.196-2.055	0.001
Age	1.006	0.987-1.026	0.522
Sex (Male/Female)	1.420	0.856-2.356	0.174
Weight	1.000	0.984-1.105	0.960
Child-Pugh grade	0.475	0.195-1.157	0.101
Fibrosis ishak score	1.640	0.706-3.813	0.250
Vascular invasion (yes/no)	1.069	0.613-1.866	0.614
FAP	1.035	0.981-1.093	0.210
Tumor grade
(G1 + G2/G3 + G4)	1.092	0.655-1.818	0.736
Pathologic stage				2.103	1.193-3.707	0.010
I/II	0.865	0.426-1.757	0.688
I/III + IV	0.445	0.250-0.793	0.006
Entire set (n = 370)
Risk score	1.957	1.646-2.327	< 0.0001	2.011	1.638-2.469	< 0.0001
Age	1.013	0.999-1.027	0.068	1.016	1.000-1.032	0.048
Sex (Male/Female)	1.166	0.817-1.664	0.396
Weight	0.998	0.988-1.007	0.615
Child-Pugh grade (A/B + C)	0.620	0.306-1.256	0.184
Fibrosis ishak score	1.232	0.742-2.045	0.365
Vascular invasion	0.962	0.650-1.424	0.846
(yes/no)
Serum AFP level	1.023	0.980-1.068	0.306
Tumor grade
(G1 + G2/G3 + G4)	1.119	0.780-1.604	0.542
Pathologic stage				2.017	1.359-2.993	0.027
I/II	0.648	0.398-1.056	0.082
I/III + IV	0.351	0.236-0.524	< 0.0001