Current guidelines for the management of non-alcoholic fatty liver disease: A systematic review with comparative analysis

Table 1 Diagnostic criteria for non-alcoholic fatty liver disease according to the various guidelines

	EASL	NICE	Asia-Pacific	AISF	AASLD
Required criteria	Steatosis in > 5% of hepatocytes by either imaging or histology	Excessive fat in the liver	Hepatic steatosis by either imaging or histology	Hepatic steatosis on either imaging or histology	Evidence of hepatic steatosis either by imaging or histology
	No other causes of steatosis	No other causes of steatosis	No other causes of steatosis	No other causes of steatosis	No other causes of steatosis
	Insulin resistance	No significant alcohol consumption	No significant alcohol consumption	No significant alcohol consumption	No significant alcohol consumption
					No coexisting chronic liver disease
Alcohol consumption threshold (men)	30 g/d	30 g/d	2 standard drink/d	30 g/d	21 standard drink/wk
			140 g/wk		294 g/wk
Alcohol consumption threshold (women)	20 g/d	20 g/d	1 standard drink/d	20 g/d	14 standard drink/wk
			70 g/wk		196 g/wk

EASL: European Association for the Study of the Liver; NICE: National Institute for Health and Care Excellence; AISF: Italian Association for the study of the Liver; AASLD: American Association for the Study of Liver Diseases; MRI: Magnetic resonance imaging.