MicroRNAs as non-invasive diagnostic biomarkers for gastric cancer: Current insights and future perspectives

Table 2 Profiling of circulating microRNAs in gastric cancer

Ref.	Year	Source	Extraction Kit	Platform	Sample Origin	GC(number of technical runs)	Controls (number of technical runs)	pooled samples	GC(number ofpooled samples)	Controls (number ofpooled samples)
Liu et al[62]	2011	Serum	phen/chlor	Solexa	China	1	1	Yes	20	20
Song et al[60]	2012	Serum	miRNeasy	qPCR-array	China	1	1	Yes	14	14
Liu et al[89]	2012	Serum	mirVana	Agilent	China	7	10	No
Konishi et al[54]	2012	Plasma	mirVana	microarray	Japan	3	3	No
Gorur et al[92]	2013	Plasma	high-pure miRNA Isolation	TaqMan Array	Turkey	1	1	Yes	20	190
Shah et al[121]	2013	Blood	miRNeasy	Geniom Biochip	Poland	1	1	Yes	8	19
Li et al[58]	2013	Plasma	mirVana	Agilent	China	20	20	No
Zhu et al[51]	2014	Plasma	miRNeasy	TaqMan Array	China	1	1	Yes	40	40
Zhang et al[53]	2015	Plasma	mirVana	Agilent	China	16	18	No
Zhou et al[88]	2015	Plasma	mirVana	Exiqon	China	3	1	Yes	30	10
Shin et al[81]	2015	Plasma	Trizol miRNeasy	miRCURY LNA	China	5	5	No
Zhang et al[78]	2015	Plasma	mirVana	Agilent	China	3	3	No
Liu et al[55]	2016	Plasma	miRNeasy	miRCURY LNA	Hong-Kong	5	5	No
Qiu et al[47]	2016	Plasma	miRNeasy	Agilent	China	1	1	Yes	5	5
Treece et al[64]	2016	Plasma	miRCURY	GastroGenus miR Panel	United States	17	14	No
Jiang et al[82]	2017	Serum	unknown	miSeq	China	2	1	Yes	20	10
Huang et al[76]	2017	Serum	mirVana	Exiqon	China	3	1	Yes	30	10
Sierzega et al[68]	2017	Serum	miRNA ABC Purification	TaqMan Array	Poland	20	20	No

GC: Gastric cancer; phen/chlor: Phenol-chloroform method.