circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling

doi:10.3748/wjg.v24.i3.323

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 24, Issue 3

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (11048)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-5) series, Tables (1-1) series.

Item

Count

PDF

628

WORD

231

HTML

5366

Figures (1-5)

282

Tables (1-1)

230

Sum=6737

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

836

Download

911

Sum=1747

Publishing Process of This Article

Item

Count

Browse

1172

Download

1392

Sum=2564

Jan 21, 2018 (publication date) through Nov 23, 2024

Times Cited of This Article

Times Cited (73)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastroenterol. Jan 21, 2018; 24(3): 323-337
Published online Jan 21, 2018. doi: 10.3748/wjg.v24.i3.323

Full Size Figure Download Figure

Figure 5 Schematic representation exhibits the circRNA_0046366/miR-34a/PPARα axis underlying occurrence and resolution of hepatocellular steatosis. In contrast to the hepatic steatogenesis that occurs upon its deficiency, circRNA_0046366 restoration abrogates the inhibitory effect of miR-34a on PPARα by antagonizing the miRNA-mRNA interaction. PPARα normalization transcriptionally activates the lipometabolic genes, which further ameliorates hepatic steatosis by regaining lipid homeostasis. mi: Micro; PPAR: Peroxisome proliferator-activated receptor.

Citation: Guo XY, Sun F, Chen JN, Wang YQ, Pan Q, Fan JG. circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling. World J Gastroenterol 2018; 24(3): 323-337
URL: https://www.wjgnet.com/1007-9327/full/v24/i3/323.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i3.323