Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients

Table 5 Univariate and multivariate analysis of chronic fatigue in Crohn’s disease (n = 227)

	Univariate OR (95%CI)		P value	Multivariate OR (95%CI)		P value
Age, years	1.02	1.00, 1.04	0.10
Gender (ref. male)	1.27	0.71, 2.26	0.41	1.11	0.61, 2.01	0.74
25-OH-D < 50 nmol/L (ref.)	1.00
25-OH-D 50-75	0.65	0.33, 1.29	0.22
25-OH-D > 75	1.25	0.56, 2.78
HBI ≥ 5	2.71	1.50, 4.91	< 0.01	2.67	1.47, 4.87	< 0.01
CRP ≥ 5 mg/L	1.18	0.64, 2.19	0.59
Calprotectin ≥ 100 mg/kg	0.56	0.29, 1.10	0.56
Depressive symptoms1	4.77	2.19, 10.39	< 0.01	3.65	1.61, 8.27	< 0.01
Sleep disturbance	4.18	2.00, 8.74	< 0.01	3.02	1.38, 6.61	< 0.01

¹HADS-D: Hospital Anxiety and depression score - depression subscore ≥ 8. CD: Crohn’s disease; HBI: Harvey Bradshaw index; CRP: C-reactive protein.