Fatigue is not associated with vitamin D deficiency in inflammatory bowel disease patients

Table 1 Socio-demographic and clinical data n (%)

	UC (n = 178)	CD (n = 227)	P value
Age median, years (range)	40 (18-76)	40 (18-77)	0.92
Gender
Female	87 (48)	112 (49)	0.77
Disease duration median, years (range)	6 (0-46)	11 (0-50)	< 0.01
Total fatigue, median (range)	16 (3-30)	15 (0-33)	0.55
Chronic fatigue	52 (29)	65 (28)	0.93
25-OH-D concentration nmol/L
< 50	78 (44)	125 (55)	0.07
50-75	76 (43)	68 (30)	< 0.01
> 75	24 (13)	34 (15)	0.61
HADS-D ≥ 8	25 (14)	32 (14)	0.99
Sleep disturbance	44 (25)	36 (16)	0.03
Disease activity
SCCAI ≥ 5	53 (29)
HBI ≥ 5		103 (46)
Fecal calprotectin ≥ 100 mg/kg (missing n = 82)	61 (34)	86 (38)
CRP ≥ 5 mg/L (missing n = 10)	50 (28)	76 (33)
UC extent, Montreal classification
E1 - Proctitis	19 (11)
E2 - Left-sided colitis	58 (32)
E3 - Extensive colitis	101 (56)
CD localization, Montreal classification
L1 - Terminal ileum		74 (32)
L2 - Colon		48 (21)
L3 - Ileocolon		75 (33)
L4 - Upper GI		31 (14)
Current use of medication
Biologics	52 (29)	113 (50)	< 0.01
5-ASA	137 (77)	23 (10)	< 0.01
Prednisolone	26 (14)	19 (8)	0.05
AZA / MTX	46 (26)	87 (38)	0.02

UC: Ulcerative colitis; CD: Crohn’s disease; SCCAI: Simple Clinical Colitis Activity Index; HBI: Harvey Bradshaw index; ASA: Aminosalicylic acid; AZA: Azathioprine; MTX: Methotrexate; CRP: C-reactive protein; HADS-D: Hospital Anxiety and depression score - depression subscore.