Impact of hyperglycemia on autoimmune pancreatitis and regulatory T-cells

Figure 1 Experimental protocol of the hyperglycemic autoimmune pancreatitis model. 28-40 wk old- MRL/MpJ mice were intraperitoneally (ip) injected with streptozotocin on day 1-5 (group: STZ), while one age-matched control cohort was ip injected with the appropriate vehicle (group: Sham). The tissue was harvested on day 113-116; (A) Treatment with STZ increased the blood glucose concentration; (B) and reduced the body weight on day 113-116; (C) Box plots indicate the median, the 25^th and 75^th percentiles in the form of a box, and the 10^th and 90^th percentiles as whiskers. The number of animals evaluated was n = 19 (Sham) and n = 17 (STZ). Differences between the indicated cohorts are indicated as significant. ^aP < 0.001; ^bP = 0.009. STZ: Streptozotocin-treated.