Role of colectomy in preventing recurrent primary sclerosing cholangitis in liver transplant recipients

Table 3 Summary of study outcomes on impact of colectomy on recurrent primary sclerosing cholangitis, inflammatory bowel disease-specific risk factors and non-inflammatory bowel disease-specific risk factors for recurrent primary sclerosing cholangitis

Ref.	Year	Colectomy	IBD-specific risk factor for rPSC	non-IBD risk factor for rPSC
1Cholongitas et al[21]	2008	No effect	Presence of UC post-LT	Need for maintenance steroids post-LT
Alabraba et al[20]	2009	Protective (pre- and peri-LT)	Presence of intact (i.e., retained) colon (independent of IBD or UC)	EDC grafts
Moncrief et al[24]	2010	No effect	None	At least one episode of ACR; CMV mismatch
Gelley et al[22]	2014	No effect	Severe active IBD	Higher donor BMI Younger recipient age
1Ravikumar et al[25]	2015	Protective (univariate analysis)	Presence of UC post-LT	Younger recipient age
Hildebrand et al[23]	2016	No effect	IBD, UC, and in particular active colitis post-LT	Higher donor age; Higher INR at LT

¹Studies reporting exclusively on ulcerative colitis. ACR: Acute cellular rejection; BMI: Body mass index; CMV: Cytomegalovirus; EDC: Extended donor criteria; IBD: Inflammatory bowel disease; INR: International normalized ratio; LT: Liver transplantation; rPSC: Recurrent primary sclerosing cholangitis; UC: Ulcerative colitis.