Multikinase inhibitor-associated hand-foot skin reaction as a predictor of outcomes in patients with hepatocellular carcinoma treated with sorafenib

doi:10.3748/wjg.v24.i28.3155

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 28, 2018; 24(28): 3155-3162
Published online Jul 28, 2018. doi: 10.3748/wjg.v24.i28.3155

Table 1 Baseline characteristics of patients

Patient features	n (%)
Total No. of patients	40
Age (yr)
Median (range)	71 (48-89)
Sex
Male	31 (78)
Female	9 (12)
Child-Pugh class
A	36 (90)
B	4 (10)
Underlying cause
HCV	23 (58)
HBV	10 (25)
Others	7 (17)
Portal vein thrombosis	11 (28)
Liver only	26 (60)
Metastatic disease	24 (40)
AFP (ng/mL)
> 100	26 (65)
≤ 100	14 (35)
DCP (mAU/mL)
> 1000	19 (48)
≤ 1000	21 (52)
BCLC stage
B	16 (40)
C	24 (60)
Intervention by pharmacists
Yes	22 (55)
No	18 (45)

AFP: Alpha-fetoprotein; BCLC: Barcelona Clinic Liver Cancer; DCP: Des-gamma-carboxy prothrombin; HCV: Hepatitis C virus; HBV: Hepatitis B virus.

Citation: Ochi M, Kamoshida T, Ohkawara A, Ohkawara H, Kakinoki N, Hirai S, Yanaka A. Multikinase inhibitor-associated hand-foot skin reaction as a predictor of outcomes in patients with hepatocellular carcinoma treated with sorafenib. World J Gastroenterol 2018; 24(28): 3155-3162
URL: https://www.wjgnet.com/1007-9327/full/v24/i28/3155.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i28.3155