Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update

Figure 2 Dual regulatory effect of aldehyde dehydrogenase 2 (ALDH2) on autophagy. During ischemia, AMPK is activated to promote “cytoprotective” autophagy due to mTOR inhibition. On the other hand, the activation of Akt during the phase of reperfusion inhibits “deleterious” autophagy, which is associated with apoptosis, thus reducing organ damage.