MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside

doi:10.3748/wjg.v24.i27.2949

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Jul 21, 2018 (publication date) through Nov 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 21, 2018; 24(27): 2949-2973
Published online Jul 21, 2018. doi: 10.3748/wjg.v24.i27.2949

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Figure 1 MicroRNA dysregulation and colorectal cancer progression. Altered expression of representative miRNAs are shown in different stages of CRC (in bold: Normal epithelium → early adenoma → late adenoma → carcinoma → metastasis). Upregulation or downregulation of miRNAs can affect signaling pathways and propel progression of CRC, leading to angiogenesis, cell invasion, metastasis and inhibition of apoptosis. APC: adenomatous polyposis coli; CRC: Colorectal cancer; KRAS: Kirsten rat sarcoma viral oncogene homolog; TP53: tumor protein p53.

Citation: To KK, Tong CW, Wu M, Cho WC. MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside. World J Gastroenterol 2018; 24(27): 2949-2973
URL: https://www.wjgnet.com/1007-9327/full/v24/i27/2949.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i27.2949