Copyright
©The Author(s) 2018.
World J Gastroenterol. Jul 21, 2018; 24(27): 2949-2973
Published online Jul 21, 2018. doi: 10.3748/wjg.v24.i27.2949
Published online Jul 21, 2018. doi: 10.3748/wjg.v24.i27.2949
Table 7 miRNA therapeutics investigated in animal models of colorectal cancer
miRNA | Animal model | Restoring or suppressing miRNA function | Therapeutic outcome | Ref. |
miR-34a | Transgenic mice | Restoring | Anti-tumor | [126] |
miR-135b | Xenotranplantation of tumor-derived organoids to mice | Suppression (antisense) | Anti-tumor | [129] |
miR-143 | Mice xenograft | Restoring | Anti-tumor | [132] |
miR-145 | Mice xenograft | Restoring | Negative effect | [132] |
miR-4689 | Mice xenograft | Restoring (mimic) | Anti-tumor | [135] |
- Citation: To KK, Tong CW, Wu M, Cho WC. MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside. World J Gastroenterol 2018; 24(27): 2949-2973
- URL: https://www.wjgnet.com/1007-9327/full/v24/i27/2949.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i27.2949