Copyright
©The Author(s) 2018.
World J Gastroenterol. Jul 21, 2018; 24(27): 2949-2973
Published online Jul 21, 2018. doi: 10.3748/wjg.v24.i27.2949
Published online Jul 21, 2018. doi: 10.3748/wjg.v24.i27.2949
miRNA | Drug(s) affected | Known molecular target(s) in CRC | Ref. |
Overexpression of miRNA causing drug resistance to conventional chemotherapeutic drugs | |||
Let-7g | S-1 (Tegafur/gimeracil/oteracil) | Cyclin D, c-myc, E2F, RAS | [229] |
miR-10b | 5-FU | BIM | [230] |
miR-19b | 5-FU | MYBL2 | [231] |
miR-20a | 5-FU, oxaliplatin | BNIP2 | [170] |
miR-21 | 5-FU | hMSH2 and hMSH6 | [120] |
miR-23a | 5-FU | APAF-1 | [149] |
miR-31 | 5-FU | - | [232] |
miR-140 | 5-FU | HDAC4 | [233] |
miR-148a | 5-FU, oxaliplatin | - | [92] |
miR-181b | S-1, 5-FU | Cyclin D, c-myc, E2F, RAS | [229] |
miR-192/miR-215 | 5-FU | DHFR | [234,235] |
miR-195 | 5-FU | WEE1 | [236] |
miR-203 | Oxaliplatin | ATM | [154] |
miR-224 | 5-FU | - | [237] |
miR-520g | 5-FU, oxaliplatin | p21 | [238] |
miR-587 | 5-FU | PPP2R1B | [151] |
miR-625-3p | Oxaliplatin | - | [94] |
Downregulation of miRNA causing drug resistance to conventional chemotherapeutic drugs | |||
miR-34a | 5-FU, oxaliplatin | SIRT1, KIT, LDHA, TGF-β, SMAD4 | [239-241] |
miR-139-5p | 5-FU | NOTCH-1 | [242] |
miR-153 | Oxaliplatin | FOXO3 | [243] |
miR-194 | Oxaliplatin, irinotecan | HMGA2 | [244] |
miR-200 family | 5-FU | EMT-related genes | [245] |
miR-200b-3p | Oxaliplatin | PRDX2 | [246] |
miR-203 | 5-FU | TYMS | [247] |
miR-218 | FOLFOX | EZH2 | [248] |
miR-761 | 5-FU | FOXM1 | [249] |
miR-1915 | Oxaliplatin | BCL2 | [155] |
miR-141/miR-200c | Oxaliplatin | ZEB1 | [250] |
miR-18a*/miR-4802 | 5-FU, capecitabine | ATG7, ULK1 | [251] |
Overexpression of miRNA causing drug resistance to molecular targeted drugs | |||
miR-31 | Cetuximab | - | [252] |
miR-126 | Bevacizumab | VEGF | [104] |
miR-100/miR-125b | Cetuximab | Wnt/β-catenin negative regulators | [253] |
Downregulation of miRNA causing drug resistance to molecular targeted drugs | |||
Let-7 family | Cetuximab, panitumumab | KRAS | [115,223] |
miR-7 | Cetuximab | EGFR, ERK1/2, AKT | [97] |
- Citation: To KK, Tong CW, Wu M, Cho WC. MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside. World J Gastroenterol 2018; 24(27): 2949-2973
- URL: https://www.wjgnet.com/1007-9327/full/v24/i27/2949.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i27.2949