MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside

Table 3 A list of representative miRNAs identified in fecal samples from colorectal cancer patients that are of prognostic value

miRNA	Method of detection	Patient number	Observations and correlation with clinical outcome	Ref.
miR-135b	qRT-PCR	424	miR-135b showed a significant increasing trend across the adenoma to cancer sequence. miR-135b level may be used to differentiate between different stages of CRC. Stool miR-135b level dropped significantly upon removal of CRC or advanced adenoma.	[75]
miR-19-b-3p, miR-20a-5p, miR-21-3p, miR-92a-3p, miR-141	qRT-PCR	20	Expression levels of three out of the five overexpressing miRNAs returned to values comparable to normal controls after curative surgery; this was correlated with the	[213]
12 upregulated and 8 downregulated miRNA panel	miRNA microarray, qRT-PCR	60	A panel of 12 upregulated miRNAs (miR-7, miR-17, miR-20a, miR-21, miR-92a, miR-96, miR-106a, miR-134, miR-183, miR-196a, miR-199a-3p, miR-214) and 8 downregulated miRNAs (miR-9, miR-29b, miR-127-5p, miR-138, miR-143, miR-146a, miR-222, miR-938) were found to differentiate not only CRC cases from healthy subjects but also differentiate TNM stages with high sensitivity and specificity.	[74]