Copyright
©The Author(s) 2018.
World J Gastroenterol. Jul 21, 2018; 24(27): 2949-2973
Published online Jul 21, 2018. doi: 10.3748/wjg.v24.i27.2949
Published online Jul 21, 2018. doi: 10.3748/wjg.v24.i27.2949
Table 3 A list of representative miRNAs identified in fecal samples from colorectal cancer patients that are of prognostic value
miRNA | Method of detection | Patient number | Observations and correlation with clinical outcome | Ref. |
miR-135b | qRT-PCR | 424 | miR-135b showed a significant increasing trend across the adenoma to cancer sequence. miR-135b level may be used to differentiate between different stages of CRC. Stool miR-135b level dropped significantly upon removal of CRC or advanced adenoma. | [75] |
miR-19-b-3p, miR-20a-5p, miR-21-3p, miR-92a-3p, miR-141 | qRT-PCR | 20 | Expression levels of three out of the five overexpressing miRNAs returned to values comparable to normal controls after curative surgery; this was correlated with the | [213] |
12 upregulated and 8 downregulated miRNA panel | miRNA microarray, qRT-PCR | 60 | A panel of 12 upregulated miRNAs (miR-7, miR-17, miR-20a, miR-21, miR-92a, miR-96, miR-106a, miR-134, miR-183, miR-196a, miR-199a-3p, miR-214) and 8 downregulated miRNAs (miR-9, miR-29b, miR-127-5p, miR-138, miR-143, miR-146a, miR-222, miR-938) were found to differentiate not only CRC cases from healthy subjects but also differentiate TNM stages with high sensitivity and specificity. | [74] |
- Citation: To KK, Tong CW, Wu M, Cho WC. MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside. World J Gastroenterol 2018; 24(27): 2949-2973
- URL: https://www.wjgnet.com/1007-9327/full/v24/i27/2949.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i27.2949