Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature

Figure 2 Pathological findings. A: Representative histological photograph of the specimens of endoscopic submucosal dissection (HE; × 50). Proliferation of gastric adenocarcinoma of the fundic gland type (GA-FG) are observed at the deep layer of the lamina propria mucosae in the left half of the photo (blue dot line: the border of GA-FG). Adjacent to the GA-FG, proliferation of the signet-ring cell carcinoma producing intra- and extracellular mucin is observed in the right half of the photo (yellow dotted line: border of the signet-ring cell carcinoma). Intestinal metaplasia was observed at the mucosa surrounding the signet-ring cell carcinoma (arrows); B: Structure and differentiation toward the surfaces of the fundic gland were significantly disturbed at the GA-FG compared to the normal fundic glands (HE; × 50). The blue line is the border of the GA-FG and the normal fundic glands. The mucosal surface was covered with non-neoplastic foveolar epithelium. Intestinal metaplasia cannot be observed in this photo; C: GA-FG invaded into the submucosal layer (HE; × 100).