Impact of the number of examined lymph nodes on outcomes in patients with lymph node-negative gallbladder carcinoma

Table 3 Multivariate analyses for overall survival in patients with lymph node-negative gallbladder carcinoma

Variable	Entire cohortn = 893 (100%)		Stage I1n = 228 (25.5%)		Stage II1n = 444 (49.7%)		Stage IIIA1n = 221 (24.7%)
	HR (95%CI)	aP	HR (95%CI)	bP	HR (95%CI)	cP	HR (95%CI)	dP
Age, yr	1.001 (1.000-1.002)	0.504	1.001 (1.000-1.002)	0.934	1.001 (1.000-1.002)	0.449	1.001 (1.000-1.002)	0.057
Sex
Male	1		1		1		1
Female	0.684 (0.532-0.879)	0.003	0.317 (0.156-0.645)	0.002	0.553 (0.346-0.881)	0.013	0.494 (0.299-0.818)	0.006
Race
White	1		1		1		1
Black	1.475 (1.008-2.160)	0.046	4.593 (1.625-12.981)	0.004	1.645 (0.775-3.490)	0.195	2.245 (0.904-5.575)	0.082
Others	0.821 (0.551-1.224)	0.334	0.262 (1.975)	0.719	0.509 (0.245-1.056)	0.070	1.362 (0.609-3.047)	0.452
Grade1
Well	1		1		1		1
Moderate	0.840 (0.609-1.157)	0.286	0.418 (0.194-0.902)	0.026	1.568 (0.905-2.715)	0.109	0.297 (0.125-0.704)	0.006
Poor	1.291 (0.908-1.835)	0.155	1.339 (0.449-3.994)	0.601	2.412 (1.306-4.453)	0.005	0.629 (0.259-1.531)	0.307
Undifferentiated	2.101 (0.891-4.954)	0.090	/	/	4.059 (1.033-15.951)	0.045	1.434 (0.323-6.373)	0.636
Unknown	0.856 (0.503-1.455)	0.565	0.384 (0.134-1.106)	0.076	2.376 (0.857-6.583)	0.096	0.260 (0.068-1.003)	0.050
Radiation
No	1		1		1		1
Yes	0.727 (0.515-1.027)	0.071	1.055 (0.302-3.688)	0.933	0.781 (0.430-1.419)	0.417	0.390 (0.215-0.708)	0.002
No. of LNs examined	1.001 (1.000-1.002)	0.162	1.001 (1.000-1.002)	0.910	1.001 (1.000-1.002)	0.382	1.001 (1.000-1.002)	0.167
Stage1
I	1		/	/	/	/	/	/
II	1.089 (0.793-1.497)	0.598	/	/	/	/	/	/
IIIA	3.730 (2.635-5.280)	0.000	/	/	/	/	/	/

¹AJCC/TNM 8^th edition. OS: Overall survival.