Impact of the number of examined lymph nodes on outcomes in patients with lymph node-negative gallbladder carcinoma

Table 2 Survival by lymph node group and stage

Number of LN	Entire cohort n = 893 (100%)	Stage I1n = 228 (25.5%)	Stage II1n = 444 (49.7%)	Stage IIIA1n = 221 (24.7%)
1 LN
Patients (n)	398	121	189	88
Median OS, mo	18	24	20	10
3-yr SR (95%CI)	0.503 (0.474-0.532)	0.603 (0.553-0.653)	0.608 (0.566-0.650)	0.271 (0.217-0.325)
5-yr SR (95%CI)	0.393 (0.361-0.425)	0.473 (0.418-0.528)	0.445 (0.394-0.496)	0.177 (0.128-0.226)
2 LNs
Patients (n)	129	35	68	26
Median OS, mo	28	43	27	15
3-yr SR (95%CI)	0.711 (0.665-0.757)	0.808 (0.737-0.879)	0.775 (0.713-0.837)	0.425 (0.317-0.533)
5-yr SR (95%CI)	0.579 (0.524-0.634)	0.725 (0.640-0.810)	0.586 (0.504-0.668)	0.340 (0.225-0.455)
3 LNs
Patients (n)	85	20	33	32
Median OS, mo	21	30	27	11
3-yr SR (95%CI)	0.587 (0.525-0.649)	0.722 (0.603-0.841)	0.697 (0.606-0.788)	0.379 (0.277-0.481)
5-yr SR (95%CI)	0.466 (0.396-0.536)	0.602 (0.454-0.750)	0.639 (0.539-0.739)	0.203 (0.109-0.297)
4 LNs
Patients (n)	55	8	31	16
Median OS, mo	22	22	27	10
3-yr SR (95%CI)	0.638 (0.560-0.716)	0.833 (0.681-0.985)	0.760 (0.671-0.849)	0.295 (0.154-0.446)
5-yr SR (95%CI)	0.533 (0.438-0.628)	0.833 (0.681-0.985)	0.652 (0.526-0.778)	0.148 (0.022-0.274)
5 LNs
Patients (n)	43	10	21	12
Median OS, mo	24	38	24	18
3-yr SR (95%CI)	0.750 (0.671-0.829)	0.857 (0.725-0.989)	NA	0.292 (0.133-0.451)
5-yr SR (95%CI)	0.652 (0.557-0.747)	0.714 (0.543-0.885)	0.857 (0.725-0.989)	0.146 (0.016-0.276)
≥ 6 LNs
Patients (n)	183	34	102	47
Median OS, mo	26	26	26	21
3-yr SR (95%CI)	0.696 (0.655-0.737)	0.817 (0.731-0.903)	0.753 (0.701-0.805)	0.498 (0.412-0.584)
5-yr SR (95%CI)	0.594 (0.547-0.641)	0.817 (0.731-0.903)	0.671 (0.610-0.732)	0.306 (0.221-0.391)

¹AJCC/TNM 8^th edition. LN: Lymph node; OS: Overall survival; SR: Survival rate; NA: Not available.