Systematic review and meta-analysis on the association of tuberculosis in Crohn’s disease patients treated with tumor necrosis factor-α inhibitors (Anti-TNFα)

Figure 3 Relationship between the estimated Mycobacterium tuberculosis infection risk difference and the corresponding standard error of the estimate. Risk difference was calculated after arcsine transformation of Mycobacterium tuberculosis incidence (Arcus sinus difference, ASD). The dashed vertical line indicates the overall arcsine difference found, and the diagonal lines indicate the expected 95% confidence intervals associated with the expected mean ASD for clinical trials with various numbers of study subjects.