Intra-individual comparison of therapeutic responses to vascular disrupting agent CA4P between rodent primary and secondary liver cancers

Figure 4 Changes of semiquantitative dynamic contrast-enhanced parameter of primary hepatocellular carcinomas and implanted liver R1-tumors and quantification of combretastatin-A4-phosphate-induced tumoral necrosis. A: Representative contrast enhancement-time curves of a primary HCC and a secondary liver R1-tumor before, and 1 h and 12 h after CA4P treatment, for calculating tumor AUC30 at different time points; B: Quantitative changes of tumor blood supply between HCCs and R1-tumors at baseline and 1 h and 12 h after CA4P treatment indicated by AUC30; C: Bar chart comparing the percentile tumoral necrosis between primary HCCs and implanted liver R1 at 12 h after CA4P therapy, which was estimated by postmortem HE staining. ^aP < 0.05, ^bP < 0.01. AUC30: Area under the time signal intensity curve; HCC: Hepatocellular carcinoma.