Intra-individual comparison of therapeutic responses to vascular disrupting agent CA4P between rodent primary and secondary liver cancers

Figure 3 Intra-individual comparison of therapeutic responses to combretastatin-A4-phosphate between a primary hepatocellular carcinoma and a hepatic R1 allograft distributed in the same liver lobe. A: T2WIs (1-1’’), T1WIs (2-2’’) and CE-T1WIs (3-3’’) of an implanted R1-tumor (green arrows) and a primary HCC (orange arrows) both located in the same left liver lobe at baseline and 1 h and 12 h after CA4P therapy; B: Corresponding macroscopic photographs of the left liver lobe (top panel) and liver blocks (middle panels) in 2-mm thickness corresponding to the transversal MRI, and microangiograms (bottom panels) of tumor-bearing liver block, revealing a R1-tumor (green circle) and a primary HCC (orange circle); C: Corresponding photomicrographs of R1-tumor (left column) and primary HCC (right column). (HE staining; upper panels, × 12.5 original magnification, scale bar = 800 μm; lower panels, × 100 original magnification, scale bar = 100 μm, × 400 original magnification, scale bar = 25 μm). HCC: Hepatocellular carcinoma; L: Liver; N: Tumoral necrosis; T: Viable tumor.