Gastric cancer in Alaska Native people: A cancer health disparity

Table 1 Comparative epidemiology of gastric cancer in United States Non-Hispanic White and Alaska Native populations n (%)

	United States			P1 value
	Non-Hispanic White	Alaska Native-SEER	Alaska Native Hospital
Population (in millions)23	274.6	0.14	0.14
Cancer registry summary
Registry type (number)	Population based (SEER 18)	Population based (SEER 18)	Hospital based (1)
Years included	2006-2014	2006-2014	2006-2014
Incident cases	40717	164	132
Calculated incidence rate4
Male	12.1	26.7	22.8
Female	3.4	18.7	13.6
Gender				0.01
Male	30141 (74.0)	95 (57.9)	82 (62.1)
Female	10576 (26.0)	69 (42.1)	50 (37.8)
Age				< 0.00015
Median (yr)	69.2 ± 0.07	60.4 ± 1.3	59.9 ± 1.2
< 20-34	258 (0.6)	4 (2.4)	3 (2.3)
35-44	926 (2.3)	9 (5.5)	9 (6.8)
45-54	4150 (10.2)	44 (26.8)	39 (29.5)
55-64	9224 (22.7)	41 (25.0)	28 (21.2)
65-74	11089 (27.2)	38 (23.2)	30 (22.7)
75-84	10144 (24.9)	23 (14.0)	19 (14.4)
> 84	4927 (12.1)	5 (3.0)	4 (3.0)
Anatomic site				< 0.00017
Cardia	26387 (64.8)	38 (23.2)	22 (16.7)
GE JX	14502 (35.6)	14 (8.5)	12 (9.1)
Non-cardia	8659 (21.3)	86 (52.4)	80 (60.6)
Fundus	970 (2.4)	4 (2.4)	12 (9.1)
Body6	3726 (9.2)	52 (30.0)	33 (25.0)
Antrum	3483 (8.6)	22 (13.4)	18 (13.6)
Pylorus	480 (1.2)	11 (6.7)	17 (12.9)
Overlap (multifocal)	1523 (3.7)	9 (5.5)	27 (20.5)
Unspecified	4148 (10.2)	31 (18.9)	3 (2.3)
Histological appearance				< 0.00018
Adenocarcinoma, NOS	33,921 (83.3)	126 (76.8)	80 (60.6)
Linitis Plastica, AC	172 (0.4)	1 (0.6)	2 (1.5)
Mucinous, AC	626 (1.5)	3 (1.8)	5 (3.8)
Tubular, AC	168 (0.5)	1 (0.6)	1 (0.8)
Papillary, AC	91 (0.2)	1 (0.6)	1 (0.8)
Mixed Cell, AC	560 (1.4)	1 (0.6)	0 (0)
Signet Ring	5179 (12.7)	31 (18.9)	52 (39.4)
Stage				0.002
I	8901 (21.9)	35 (21.3)	28 (21.1)
II	5662 (13.9)	24 (14.6)	24 (18.0)
III	5327 (13.1)	14 (8.5)	14 (11.4)
IV	15323 (37.6)	75 (45.7)	66 (50.0)
Unspecified	5504 (13.5)	16 (9.8)	0 (0)

¹Bold type indicates statistical significance (P < 0.05), statistics were performed on SEER Non-Hispanic White and Hospital based Alaska Native populations;

²Population for US White 2010, US Census;

³Population for AK Native 2010, Alaska Department of Labor and workforce development;

⁴Incidence rates, per 100000 person years and are age-adjusted using the 2000 US standard population;

⁵Wilcoxon rank sum test;

⁶Body includes body, lesser curvature, and greater curvature;

⁷Chi-square test between Cardia, Non-Cardia, Overlapping, and Unspecified;

⁸Chi-square test between adenocarcinoma and Signet Ring. NOS: Not otherwise specified; AC: Adenocarcinoma; GE JX: Gastroesophageal junction; SEER: Surveillance and Epidemiology End Results Program (SEER) 18 dataset; AC: Adenocarcinoma; JX: Junction.