Bioinformatics analysis of aberrantly methylated-differentially expressed genes and pathways in hepatocellular carcinoma

doi:10.3748/wjg.v24.i24.2605

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 28, 2018; 24(24): 2605-2616
Published online Jun 28, 2018. doi: 10.3748/wjg.v24.i24.2605

Table 4 Hub genes for hypomethylated, highly expressed genes ranked in cytoHubba

Catelogy	Rank methods in cytoHubba
Catelogy	MCC	MNC	Degree	EPC	Closeness	Radiality
Gene symbol top 10	*CDC45*	*CDC45*	*CDC45*	*CDC45*	*CDKN3*	*CDKN3*
	*DTL*	*AURKB*	*AURKB*	*AURKB*	*CDC45*	PRKDC
	RACGAP1	*DTL*	*CDKN3*	*CDKN3*	*AURKB*	*CDC45*
	*AURKB*	RACGAP1	*DTL*	*DTL*	PTTG1	PTTG1
	CDC20	CDC20	RACGAP1	RACGAP1	*DTL*	*MCM10*
	*CDKN3*	*CDKN3*	CDC20	CDC20	*MCM2*	BRCA1
	RRM2	*MCM2*	*MCM2*	*MCM2*	*MCM10*	PI3
	*MCM2*	PTTG1	PTTG1	PTTG1	RACGAP1	*AURKB*
	*MCM10*	RRM2	RRM2	RRM2	CDC20	*MCM2*
	MKI67	*MCM10*	*MCM10*	*MCM10*	RRM2	*DTL*

Bold gene symbols were the overlap hub genes in top 10 by six ranked methods respectively in cytoHubba. MCC: Maximal cilque centrality; MNC: Maximum neighborhood component; Degree: Node connect degree; EPC: Edge percolated component.

Citation: Sang L, Wang XM, Xu DY, Zhao WJ. Bioinformatics analysis of aberrantly methylated-differentially expressed genes and pathways in hepatocellular carcinoma. World J Gastroenterol 2018; 24(24): 2605-2616
URL: https://www.wjgnet.com/1007-9327/full/v24/i24/2605.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i24.2605