Bioinformatics analysis of aberrantly methylated-differentially expressed genes and pathways in hepatocellular carcinoma

doi:10.3748/wjg.v24.i24.2605

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Jun 28, 2018; 24(24): 2605-2616
Published online Jun 28, 2018. doi: 10.3748/wjg.v24.i24.2605

Table 2 KEGG pathway analysis of methylated-differentially expressed genes related with hepatocellular carcinoma

Category		Term	Count	%	P value	Gene
Hyper-LGs	KEGG_PATHWAY	hsa04610:Complement and coagulation cascades	7	2.64	6.62E-03	C7, CR1, CD55, THBD, MASP1, SERPINE1, PLAUR
	KEGG_PATHWAY	hsa05414:Dilated cardiomyopathy	7	2.64	2.50E-02	LAMA2, ITGA9, ADCY1, ADRB1, ITGB8, ADCY5, TGFB3
	KEGG_PATHWAY	hsa05200:Pathways in cancer	15	5.66	2.94E-02	FGFR2, PTGS2, FLT3, PIK3CD, FZD1, TGFB3, MMP2, WNT2, LAMA2, RAC2, NKX3-1, LAMC2, WNT11, HHIP, GSTP1
	KEGG_PATHWAY	hsa04310:Wnt signaling pathway	9	3.40	3.16E-02	WNT2, SFRP5, NKD2, RAC2, PRICKLE1, SFRP1, FZD1, WNT11, FOSL1
	KEGG_PATHWAY	hsa04062:Chemokine signaling pathway	10	3.77	3.97E-02	CXCL1, ADCY1, DOCK2, CCL23, RAC2, TIAM1, ADCY5, PIK3CD, CCL19, CXCL6
Hypo-HGs	KEGG_PATHWAY	hsa04110:Cell cycle	7	4.38	2.32E-03	CCNE2, E2F2, PRKDC, CDC20, MCM2, SFN, PTTG1
	KEGG_PATHWAY	hsa00140:Steroid hormone biosynthesis	3	1.88	9.07E-02	CYP17A1, CYP7A1, UGT2B11

Top five terms were listed on the basis of P value if over five terms in the category, Hyper-LGs (hypermethylated, lowly expressed genes), Hypo-HGs (hypomethylated, highly expressed genes).

Citation: Sang L, Wang XM, Xu DY, Zhao WJ. Bioinformatics analysis of aberrantly methylated-differentially expressed genes and pathways in hepatocellular carcinoma. World J Gastroenterol 2018; 24(24): 2605-2616
URL: https://www.wjgnet.com/1007-9327/full/v24/i24/2605.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i24.2605