Association of twelve polymorphisms in three onco-lncRNA genes with hepatocellular cancer risk and prognosis: A case-control study

doi:10.3748/wjg.v24.i23.2482

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Control Study

World J Gastroenterol. Jun 21, 2018; 24(23): 2482-2490
Published online Jun 21, 2018. doi: 10.3748/wjg.v24.i23.2482

Table 2 Association of haplotype of lncRNA gene and hepatocellular cancer risk (n)

Haplotype	Control (%)	Case (%)	OR (95%CI)	P value
HOTTIP¹
CGCA	33.54 (2.4)	407.00 (4.5)	1.91 (1.20-3.05)	0.006
CTGC	663.39 (47.3)	389.97 (43.4)	0.85 (0.71-1.01)	0.066
GTCA	604.75 (43.1)	401.77 (44.7)	1.08 (0.91-1.28)	0.406
CCAT2²
AAG	623.60 (39.8)	434.27 (42.7)	1.13 (0.96-1.33)	0.136
AAT	937.40 (59.8)	577.73 (56.9)	0.89 (0.75-1.04)	0.136
MALAT1³
CTCA	217.99 (13.8)	167.00 (16.3)	1.22 (0.08-1.52)	0.080
GCCA	934.81 (59.3)	599.74 (58.6)	0.97 (0.82-1.14)	0.718
GTCA	296.19 (18.8)	1720 (16.6)	0.86 (0.70-1.06)	0.160
GTGG	85.00 (5.4)	58.94 (5.8)	1.07 (0.76-1.51)	0.689

Haplotype for

¹HOTTIP rs3807598-rs17501292-rs2067087-rs17427960;

²CCAT2 rs3843549-rs138947056-rs6983267;

³MALAT1 rs4102217-rs591291-rs11227209-rs619586.

Citation: Wang BG, Xu Q, Lv Z, Fang XX, Ding HX, Wen J, Yuan Y. Association of twelve polymorphisms in three onco-lncRNA genes with hepatocellular cancer risk and prognosis: A case-control study. World J Gastroenterol 2018; 24(23): 2482-2490
URL: https://www.wjgnet.com/1007-9327/full/v24/i23/2482.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i23.2482