Association of twelve polymorphisms in three onco-lncRNA genes with hepatocellular cancer risk and prognosis: A case-control study

Table 1 Association of lncRNA gene single nucleotide polymorphisms and risk of hepatocellular cancer (n)

Gene	Chr. Pos.	SNP1	Loc.	Genotype	Controls (%)	Cases (%)	P2 value	OR (95%CI)	PHWE value
HOTTIP	7p15.2	rs17501292	Exon	TT	732 (91.2)	453 (87.1)		1 (Ref.)	0.190
				TG	71 (8.8)	66 (12.7)	0.021	1.52 (1.06-2.17)
				GG	0 (0)	1 (0.2)	NA	NA
				TG + GG vs TT			0.017	1.54 (1.08-2.20)
				G vs T			0.012	1.55 (1.10-2.18)
		rs2067087	Exon	GG	174 (21.7)	88 (16.9)		1 (Ref.)	0.674
				GC	405 (50.6)	263 (50.7)	0.236	1.16 (0.90-1.49)
				CC	222 (27.7)	168 (32.4)	0.015	1.49 (1.08-2.08)
				CC vs GG + GC			0.035	1.35 (1.02-1.82)
				C vs G			0.017	1.20 (1.03-1.41)
		rs17427960	Intron	CC	172 (21.7)	85 (16.7)		1 (Ref.)	0.613
				CA	387 (48.8)	259 (50.9)	0.707	1.05 (0.81-1.35)
				AA	234 (29.5)	165 (32.4)	0.032	1.78 (1.03-2.00)
				AA vs CC + CA			0.028	1.39 (1.03-1.85)
				A vs C			0.049	1.18 (1.00-1.37)
MALAT1	22q13.2	rs4102217	Promoter	GG	608 (75.1)	362 (69.6)		1 (Ref.)	0.055
				GC	180 (22.2)	148 (28.5)	0.011	1.39 (1.08-1.79)
				CC	22 (2.7)	10 (1.9)	0.481	0.76 (0.36-1.63)
				GC + CC vs GG			0.028	1.32 (1.03-1.69)
				C vs G			0.097	1.20 (0.97-1.50)

¹The sort order was according to the SNP location in its genes from 5' starting to 3' ends.

²P value was calculated by adjusted by age and gender. NA: Not available; Chr. Pos.: Chromosomal position; Loc.: Localisation; P_HWE: P value for Hardy-Weinberg Equilibrium.