Feasibility of using marginal liver grafts in living donor liver transplantation

Table 7 Impact of graft steatosis on living donor liver transplantation

Ref.	n	Conclusion	Study type
Dirican et al[9] (2015)	161	Approximately 40% of donor grafts are discarded because of severe liver steatosis	RS
Perkins et al[109] (2006)	NS	Typically steatotic livers with > 60% fat are not transplanted; with < 30% fat are usable and anticipated to have good function; with 30%-60% fat give poor results	Comments
Kotecha et al[110] (2013)	340	Hepatic steatosis is a leading cause of donor rejection in LDLT	PS
Cho et a[111]l (2010)	54	Hepatocyte replication is impaired during steatotic liver regeneration after LDLT	PS
Cho et al[112] (2006)	67	Hepatic steatosis is associated with intrahepatic cholestasis and transient hyperbilirubinemia during regeneration	PS
Cho et al[113] (2005)	55	Mildly steatotic graft did not increase the risk of graft dysfunction or morbidity in LDLT	PS
Gao et al[114] (2009)	24	Moderately steatotic (30%-60%) liver grafts provide adequate function in the first phase after transplantation and can be used for transplantation	RS
Knaak et al[115] (2017)	105	Donors with BMI > 30, in the absence of graft steatosis, are not contraindicated for LDLT	RS
Han et al[116] (2015)	211	The risk of steatosis may be determined by the relative composition of MiS and MaS, rather than the total quantitative degree	RS

LDLT: Living donor liver transplantation; RS: Retrospective study; PS: Prospective study.