Stage III should be subclassified into Stage IIIA and IIIB in the American Joint Committee on Cancer (8th Edition) staging system for pancreatic cancer

Table 3 Univariable analyses for disease-specific survival in stage III pancreatic cancer patients

Characteristics	T(1-3)N2 (n = 1526)			T4N(0-1) (n = 138)			T4N2 (n = 80)
	HR	95%CI	P	HR	95%CI	P	HR	95%CI	P
Age
18-59	Reference			Reference			Reference
60-79	1.073	0.935-1.232	0.314	1.357	0.776-2.371	0.285	2.078	1.057-4.086	0.034
> 80	1.319	1.013-1.718	0.040	2.463	0.909-6.669	0.076	1.484	0.317-6.949	0.616
Race
White	Reference			Reference			Reference
Black	1.028	0.818-1.291	0.812	1.099	0.510-2.371	0.809	0.898	0.318-2.536	0.839
Others	1.062	0.8123-1.369	0.644	0.875	0.364-2.105	0.766	1.653	0.552-4.949	0.369
Sex
Male	Reference			Reference			Reference
Female	1.006	0.884-1.144	0.933	1.067	0.672-1.694	0.784	0.469	0.236-0.933	0.031
Grade
I	Reference			Reference			Reference
II	2.145	1.604-2.867	0.000	1.341	0.599-3.005	0.476	4.537	1.314-15.664	0.017
III	2.709	2.026-3.623	0.000	1.496	0.653-3.430	0.341	9.551	2.620-34.815	0.001
IV	4.151	2.151-8.010	0.000	/	/	/	12.706	1.541-104.769	0.018
Unknown	2.038	1.382-3.006	0.000	0.562	0.163-1.937	0.361	2.463	0.461-13.177	0.292
Marital status
Single	Reference			Reference			Reference
Married	0.902	0.786-1.034	0.138	0.613	0.357-1.054	0.077	1.820	0.888-3.727	0.102
Unknown	1.021	0.655-1.590	0.928	4.531	0.961-21.369	0.056	0.190	0.018-1.981	0.165
Primary site
Head of pancreas	Reference			Reference			Reference
Other parts of pancreas	1.228	1.040-1.450	0.015	0.761	0.456-1.271	0.297	1.365	0.607-3.070	0.451
Histology
Adenomas and adenocarcinomas	Reference			Reference			Reference
Ductal and lobular neoplasms	1.066	0.937-1.214	0.333	1.126	0.686-1.849	0.639	1.946	0.874-4.335	0.103
Others	1.029	0.787-1.344	0.837	0.953	0.485-1.872	0.888	2.134	0.884-5.151	0.092