Prognostic value of hypoxia-inducible factor-1 alpha and prolyl 4-hydroxylase beta polypeptide overexpression in gastric cancer

Table 3 Multivariate analysis of significant prognostic factor for survival in gastric cancer patients

Variables	DFS			OS
	P value	HR	95%CI	P value	HR	95%CI
Bormann	0.26	1.15	0.91-1.46	0.38	1.11	0.88-1.40
Tumor Size	0.34	0.88	0.67-1.15	0.38	0.89	0.68-1.16
Tumor differentiation	0.95	0.99	0.74-1.33	0.84	1.03	0.77-1.31
Vessel invasion	0.01	0.70	0.53-0.93	0.19	0.83	0.63-1.09
Perineural invasion	0.44	0.90	0.68-1.19	0.25	0.86	0.66-1.11
TNM stage	0.00	24.65	16.04-37.87	0.00	87.72	41.21-186.68
HIF-1α expression	0.00	0.67	0.52-0.88	0.00	0.65	0.50-0.85
P4HB expression	0.04	0.76	0.58-1.00	0.65	0.94	0.72-1.23

DFS: Disease-free survival; OS: Overall survival; HIF-1α: Hypoxia-inducible factor-1α; P4HB: Prolyl 4-hydroxylase beta.