Review
Copyright ©The Author(s) 2018.
World J Gastroenterol. Jun 7, 2018; 24(21): 2236-2246
Published online Jun 7, 2018. doi: 10.3748/wjg.v24.i21.2236
Table 3 Detection of autoantibodies against tumor associated antigens in gastric cancer
Biomarker signature descriptionTechnologyStudy designSample size (GC/controls)Diagnostic valueRef.
2 TAAs-p62 and KocELISAGC vs HC135/82Sn = 19.3%, Sp = 97.6%, P < 0.01Zhang et al[84], 2001
3TAAs-IQGAP3, KRT23 and REG3APARSE assayGC vs HC (age and sex matched)48/46Sn = 22.9%, Sp = 100%, P < 0.001Xu et al[85], 2012
3 TAAs-p16, p53 and c-mycELISAGC vs HC74/82Sn = 21.6%, Sp = 97.6%; P < 0.001Looi et al[86], 2006
6 TAAs-p53, Hsp70, HCC-22-5, PrxVI, KM-HN-1 and p90ELISAGC vs HC, training set100/79Sn = 49.0%, Sp = 92.4%, P < 0.01Hoshion et al[87], 2017
GC vs HC, validation set248/74Sn = 52.0%, Sp = 90.5%, P < 0.01
7 TAAs - p53, C-myc, p16, IMP1, Koc, p62 and SurvivinELISACardia GC vs HC88/140AUC = 0.73, Sn = 64%, Sp = 87%, P < 0.001Zhou et al[41], 2015
7 TAAs - C-myc, Cyclin B1, IMP1, Koc, P53, p62 and SurvivinELISA, fixed cut-offGC vs HC91/346Sn = 52.7%, Sp = 89.9%, P < 0.01Zhang et al[88], 2003
ELISA, individual cut-offGC vs HC91/346Sn = 98.9%, Sp = 93.1%, P < 0.001Koziol et al[89], 2003
45 T7 phage-displayed TAA clones (including NY-ESO-1, DDX53, MAGE antigens etc.)T7 phage displayed TAA microarrayGC vs HC (age and sex matched)T:100/100AUC = 0.79, Sn = 59%, Sp = 90%, P < 0.001Zayakin et al[42], 2013
V:235/213AUC = 0.64, Sn = 58.7%, Sp = 55%, P < 0.001
GC vs gastritis235/100AUC = 0.76, Sn = 58.7%, Sp = 81.5%, P < 0.001
GC vs gastric ulcer235/54
64 TAAs (including MAGEA4, CTAG1, TP53, ERBB2_C and SDCCAG8 antigens etc.)Bead-based multiplex serologyGC vs HCT:155/224Sn = 0-12%, Sp = 98%; P > 0.05Werner et al[90], 2016
GC vs HCV:146/97Sn = 32%, Sp = 87%; P < 0.001
102 TAAs (including CTAG1B/CTAG2, DDX53, IGF2BP2, TP53 and MAGEA3 antigens etc.)A recombinant antigen microarrayGC vs HC829/929AUC = 0.60, Sn = 21%, Sp = 91%, P < 0.001Meistere et al[43], 2017