Copyright
©The Author(s) 2018.
World J Gastroenterol. Jun 7, 2018; 24(21): 2236-2246
Published online Jun 7, 2018. doi: 10.3748/wjg.v24.i21.2236
Published online Jun 7, 2018. doi: 10.3748/wjg.v24.i21.2236
Biomarker signature description | Technology | Study design | Sample size (GC/controls) | Diagnostic value | Ref. |
2 TAAs-p62 and Koc | ELISA | GC vs HC | 135/82 | Sn = 19.3%, Sp = 97.6%, P < 0.01 | Zhang et al[84], 2001 |
3TAAs-IQGAP3, KRT23 and REG3A | PARSE assay | GC vs HC (age and sex matched) | 48/46 | Sn = 22.9%, Sp = 100%, P < 0.001 | Xu et al[85], 2012 |
3 TAAs-p16, p53 and c-myc | ELISA | GC vs HC | 74/82 | Sn = 21.6%, Sp = 97.6%; P < 0.001 | Looi et al[86], 2006 |
6 TAAs-p53, Hsp70, HCC-22-5, PrxVI, KM-HN-1 and p90 | ELISA | GC vs HC, training set | 100/79 | Sn = 49.0%, Sp = 92.4%, P < 0.01 | Hoshion et al[87], 2017 |
GC vs HC, validation set | 248/74 | Sn = 52.0%, Sp = 90.5%, P < 0.01 | |||
7 TAAs - p53, C-myc, p16, IMP1, Koc, p62 and Survivin | ELISA | Cardia GC vs HC | 88/140 | AUC = 0.73, Sn = 64%, Sp = 87%, P < 0.001 | Zhou et al[41], 2015 |
7 TAAs - C-myc, Cyclin B1, IMP1, Koc, P53, p62 and Survivin | ELISA, fixed cut-off | GC vs HC | 91/346 | Sn = 52.7%, Sp = 89.9%, P < 0.01 | Zhang et al[88], 2003 |
ELISA, individual cut-off | GC vs HC | 91/346 | Sn = 98.9%, Sp = 93.1%, P < 0.001 | Koziol et al[89], 2003 | |
45 T7 phage-displayed TAA clones (including NY-ESO-1, DDX53, MAGE antigens etc.) | T7 phage displayed TAA microarray | GC vs HC (age and sex matched) | T:100/100 | AUC = 0.79, Sn = 59%, Sp = 90%, P < 0.001 | Zayakin et al[42], 2013 |
V:235/213 | AUC = 0.64, Sn = 58.7%, Sp = 55%, P < 0.001 | ||||
GC vs gastritis | 235/100 | AUC = 0.76, Sn = 58.7%, Sp = 81.5%, P < 0.001 | |||
GC vs gastric ulcer | 235/54 | ||||
64 TAAs (including MAGEA4, CTAG1, TP53, ERBB2_C and SDCCAG8 antigens etc.) | Bead-based multiplex serology | GC vs HC | T:155/224 | Sn = 0-12%, Sp = 98%; P > 0.05 | Werner et al[90], 2016 |
GC vs HC | V:146/97 | Sn = 32%, Sp = 87%; P < 0.001 | |||
102 TAAs (including CTAG1B/CTAG2, DDX53, IGF2BP2, TP53 and MAGEA3 antigens etc.) | A recombinant antigen microarray | GC vs HC | 829/929 | AUC = 0.60, Sn = 21%, Sp = 91%, P < 0.001 | Meistere et al[43], 2017 |
- Citation: Li TT, Liu H, Yu J, Shi GY, Zhao LY, Li GX. Prognostic and predictive blood biomarkers in gastric cancer and the potential application of circulating tumor cells. World J Gastroenterol 2018; 24(21): 2236-2246
- URL: https://www.wjgnet.com/1007-9327/full/v24/i21/2236.htm
- DOI: https://dx.doi.org/10.3748/wjg.v24.i21.2236