Regulatory polymorphism of CXCL10 rs1439490 in seronegative occult hepatitis C virus infection

doi:10.3748/wjg.v24.i20.2191

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2018; 24(20): 2191-2202
Published online May 28, 2018. doi: 10.3748/wjg.v24.i20.2191

Table 4 IL-28B single nucleotide polymorphism rs12979860 and CXCL10 single nucleotide polymorphism G-201A, C-1513T in occult hepatitis C virus infection and chronic hepatitis C virus infection patients n (%)

	Seronegative OCI patients (n=103)	Seropositive CHC patients (n=155)	P value
IL-28BSNP rs12979860
C/C	97 (94.2%)	128 (82.6%)	0.009
Non-C/C	6 (5.8%)	27 (17.4%)	0.009
CXCL10 SNP rs1439490 (G-201A)
G/G	93 (90.4%)	116 (74.8%)	0.003
G/A	9 (8.7%)	35 (22.6%)
A/A	1 (0.9%)	4 (2.6%)
CXCL10 SNP rs1440802 (C-1513T)
C/C	26 (25.2%)	40 (25.8%)	0.733
C/T	54 (52.4%)	78 (50.3%)
T/T	23 (22.4%)	37 (23.9%)

P value: OCI group compared with CHC group; P < 0.05; IL-28BSNP rs12979860 non-C/C genotype included IL-28BSNP rs12979860 C/T + T/T genotypes. OCI: Occult hepatitis C virus infection; CHC: Chronic hepatitis C virus infection.

Citation: Wang X, Wang S, Liu ZH, Qi WQ, Zhang Q, Zhang YG, Sun DR, Xu Y, Wang HG, Li ZX, Cong XL, Zhao P, Zhou CY, Wang JB. Regulatory polymorphism of CXCL10 rs1439490 in seronegative occult hepatitis C virus infection. World J Gastroenterol 2018; 24(20): 2191-2202
URL: https://www.wjgnet.com/1007-9327/full/v24/i20/2191.htm
DOI: https://dx.doi.org/10.3748/wjg.v24.i20.2191