Liver transplantation and multivisceral transplantation in the management of patients with advanced neuroendocrine tumours

Table 2 Comparison of published selection criteria for liver transplantation in neuroendocrine liver metastases, and cirrhosis with hepatocellular carcinoma

Criteria and context	Parameters
Milan NET criteria[42] Neuroendocrine liver metastases	Age < 60 G1/G2 tumour grade Primary tumour drained by the portal venous system Metastatic involvement limited to the liver Hepatic tumour burden not > 50% Six months of no tumour progression
Milan criteria[62] HCC and cirrhosis	Single tumour ≤ 5 cm Or, ≤ 3 tumours each ≤ 3 cm in size No macrovascular invasion
UCSF criteria[63] HCC and cirrhosis	Single lesion ≤ 6.5 cm Or, 2-3 lesions ≤ 4.5 cm each, with total tumour diameter ≤ 8 cm No macrovascular invasion
Navarro criteria[64] HCC and cirrhosis	Single lesion ≤ 6 cm Or, 2-3 lesions ≤ 5 cm each No macrovascular invasion
Valencia criteria[65] HCC and cirrhosis	1-3 lesions ≤ 5 cm each, total tumour dimeter ≤ 10 cm No macrovascular invasion
‘Up-to-7’ criteria[66] HCC	Number of tumours + size of tumours (in cm) ≤ 7 No microvascular invasion

HCC: Hepatocellular carcinoma; G: Grade.